• The effect of the combination of Anthemis pseudocotula, Trachyspermum, and Dracocephalum extract with antioxidant and antibacterial properties in the induced model of Helicobacter pylori infection in the stomach of rats.
  • Tohid Behpoor Anzabi,1 Maedeh Ebrahimpoor,2 Saeed Naseri,3,*
    1. Health Technology Growth Center of Ardabil University of Medical Sciences, Ardabil, Iran
    2. Department of Pathology, Imam Reza Hospital, Tabriz, Iran
    3. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


  • Introduction: Helicobacter pylori (H. pylori) is regarded as the primary etiological agent of peptic ulcer and gastric carcinoma. Claiming about 50 percent of the world population is infected with H. pylori, therapies for its eradication have failed for many reasons, including the acquired resistance against its antibiotics. Hence, the need to find new anti-H.pylori medications have become a hotspot with the urge to search for alternative, more potent, and safer inhibitors. Medicinal plants are suggested as repositories for novel synthetic substances in recent drug technology scenarios
  • Methods: In this study, 35 male rats were selected in five groups to investigate the effects of three plants' combination of aqueous extracts. After the injection of the Helicobacter bacteria strains into the stomach of the rats, sampling of the stomach tissue and blood was done.
  • Results: The results were classified as pathological and microbial findings and checked boxes. After the interpretation of gastric tissue pathology sections in mice, the treatment group with combined herbal extracts had a significant difference compared to other groups in terms of gastric ulcer healing and microbial load
  • Conclusion: The data shows that the combined aqueous extract with anti-inflammatory and antioxidant properties has been able to protect the gastric mucosa and significantly reduce the wound resulting from infection.
  • Keywords: Gastroduodenal, Infection, Anti-Helicobacter pylori, Herbal extract, Microbiology