• Potential Ability of Umbilical Cord-Derived Mesenchymal Stem Cells in The Treatment of Premature Ovarian Failure
  • samira mozaffari khosravi,1,* saman seyedabadi,2
    1. Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
    2. Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


  • Introduction: Women of reproductive age may encounter challenges related to infertility or miscarriage, due to conditions such as premature ovarian failure (POF). POF, affecting approximately one percent of women under the age of 40, can lead to infertility. Current data have suggested that utilizing stem cell therapy was the most effective approach for treating POF compared to alternative options. Among the various stem cell types, mesenchymal stem cells derived from the umbilical cord (HUC-MSCs) was a promising choice for treatment due to its features such as relatively low immunogenicity, multipotent, multiple origins, cost-effectiveness, ease of production, and high efficiency.
  • Methods: In this study, using the keywords of ovarian failure, infertility, umbilical cord-derived mesenchymal stem cells in Scopus, PubMed, Google scholar and Web of Science databases, studies in this field were searched, also using From the keywords of the study, 99 articles were obtained, and according to the intended purpose and the removal of duplicate articles, 48 ​​articles were obtained.
  • Results: In people facing challenges caused by premature ovarian failure, there are significant effects on mental and physical health. Hormonal therapies are commonly used to reduce symptoms of estrogen deficiency in women with POF, but have not been very successful. Therefore, there is a need for better treatment options to solve this problem and a lot of research has been done to find more effective solutions to treat POF. As a result of numerous researches on the use of mesenchymal stem cells derived from the umbilical cord in the treatment of premature ovarian failure, it seems that these cells can play an important role in improving and regenerating ovarian function. Among the important results of this research, we can mention the increase in the number and function of follicles, the improvement of the reproduction process, and the regular regulation of hormones. These cells appear to be able to restore ovarian function after damage from various things, including chemotherapy. Overall, it seems that umbilical cord-derived mesenchymal stem cells have a potential ability to heal and repair ovaries in the face of premature ovarian failure. These results show that the use of these cells may be an effective and innovative approach in the treatment of this lack of egg production and improve ovarian function and increase fertility opportunities in people with premature ovarian failure.
  • Conclusion: One of the ways to treat POF is the use of mesenchymal stem cells derived from the umbilical cord, these cells have an extraordinary capacity for repair and regeneration, which helps them in repairing depleted ovaries. The results of this review article indicate that the use of HUC-MSCs can be considered as a potential treatment method in these patients.
  • Keywords: Menopause, Premature, Mesenchymal Stem Cells, Infertility.