• Advancing Cancer Treatment Through the Utilization of Organoids: A review
  • Samira Shafiee,1,*
    1. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


  • Introduction: Cancer treatment remains a significant challenge due to the heterogeneity of tumors and the variability in patient responses to therapy. Traditional models for studying cancer often fail to capture the complexity of human tumors, leading to ineffective treatments. Organoids, which are 3D cultures derived from patient tumor cells, have emerged as a promising solution. They accurately replicate the architecture and functionality of actual tumors, offering a more reliable platform for studying cancer biology and testing therapeutic interventions. This review aimed to explore the latest developments in organoid technology and its implications for cancer treatment.
  • Methods: The review was conducted through a systematic literature search using databases such as PubMed, Scopus, and Web of Science. Keywords such as "organoids," "cancer treatment," "personalized medicine," and "drug testing" were utilized to identify relevant articles. Selected studies were critically analyzed to summarize key findings regarding organoid development, therapeutic applications, and biomarker identification. The review also examined case studies and clinical trials that have demonstrated the integration of organoids into oncology practice. The findings will be useful to present a cohesive understanding of the role of organoids in advancing cancer
  • Results: This review provided a comprehensive overview of the advancements in organoid technology and its applications in cancer treatment. It highlighted the potential of organoids to facilitate personalized therapy, improve drug screening processes, and deepen our understanding of tumor biology. By identifying current challenges and limitations, the review will also offer insights into future research directions, paving the way for the clinical adoption of organoid-based approaches in oncology.
  • Conclusion: The proposed review on advancing cancer treatment through the utilization of organoids aimed to provide a critical assessment of the current state of research and its implications for personalized medicine. By providing existing literature and identifying future directions, this review contributed to understanding how organoids can transform cancer therapy and improve patient outcomes. This comprehensive revirew will serve as a valuable resource for researchers, clinicians, and policymakers in the oncology research field.
  • Keywords: Organoids, Cancer Treatment, Tumor Biology, Patient-Derived Models