مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Optogenetics: Battling cancer with light
Optogenetics: Battling cancer with light
Hoda Keshmiri Neghab,1,*
1. Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran
Introduction: Gene and cell therapies are widely recognized as future cancer therapeutics but poor controllability limits their clinical applications.
Optogenetics, the use of light-controlled proteins to precisely spatiotemporally regulate the activity of genes and cells, opens up new possibilities for cancer treatment
Normal cancer treatment involves drugs that are often harmful to the body. The optogenetics technique involves injecting a gene into cells that make a light-sensitive protein. Next, they shine a laser on these cells to alter their behaviors. Different proteins will result in different behaviors.
Breast and skin cancers may be most ideal for this kind of treatment because they are easy to target with a laser, according to Levin.
Methods: Here, we introduce optogenetic approaches in cancer research, their clinical potential and challenges of incorporating optogenetics in cancer therapy. We critically discuss beneficial combinations of optogenetic technologies in cancer.
Results: optogenetics approaches can provide us with outstanding tool to extend our understanding of how cells perceive, respond, and behave in meeting with complex signals, particularly in terms of cancer evasion from the anticancer immune system functions
Conclusion: If this approach works on humans, it would place scientists closer to developing alternative drug-free treatment methods. Similarly, this method works differently than many cancer drugs, which commonly kill cells.
Reverting the cell back to its original state by hitting it with light may be the cancer treatment of the future. Optogenetics merely reverts the cell back to its normal, or non-dividing, state. Standard cancer drugs that target dividing cells are not 100 percent effective, and they often have harsh side effects. This drug-free treatment technique may be a healthier alternative to treating a volatile disease.