مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Investigating the Antibacterial Effects of Silver Nanoparticles and Grape Seed Aqueous Extract on Streptococcus mutans
Investigating the Antibacterial Effects of Silver Nanoparticles and Grape Seed Aqueous Extract on Streptococcus mutans
Ali Safar,1,*Reyhaneh Rasool Zadeh,2Reyhaneh Akrami,3Sara Ostadian,4Hadise Ahmdi,5
1. , Islamic Azad University, Najaf Abad Branch 2. Farzangan Amin Eran and Bidgol High School 3. Farzangan Amin Eran and Bidgol High School 4. Farzangan Amin Eran and Bidgol High School 5. Farzangan Amin Eran and Bidgol High School
Introduction: One of the primary contributors to tooth decay is the bacteria Streptococcus mutans which produces lactic acid that damages tooth enamel and negatively impacts the health of many individuals. Grape seed extract is rich in compounds such as polyphenols, known for their antimicrobial properties. Additionally, silver nanoparticles represent an emerging material in the field of bactericidal agents. This study aims to investigate the effects of grape seed aqueous extract and silver nanoparticles on Streptococcus mutans.
Methods: In this experimental study, we evaluated the antibacterial properties of the compounds under investigation, as well as standard antibiotics including amoxicillin, penicillin, tetracycline, and vancomycin, using the disc diffusion method. The diameters of the inhibition zones for Streptococcus mutans at concentrations of 1.56 and 200 µg/mL were measured to be 10 ± 0.1 mm and 15 ± 0.1 mm, respectively.
Results: The results indicated that Streptococcus mutans was sensitive to the antibiotic discs of amoxicillin and penicillin, resistant to tetracycline, and exhibited relative sensitivity to vancomycin. Notably, the dilutions of grape seed extract did not produce any inhibition zones.
Conclusion: These findings demonstrate that silver nanoparticles possess anti-streptococcal properties and could play a significant role in the pharmaceutical and medical industries. In contrast, the aqueous extract of grape seed did not exhibit any anti-streptococcal activity, potentially due to the type of solvent used in the extraction process.