مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Association between Helicobacter pylori infection and gastric microbiota
Association between Helicobacter pylori infection and gastric microbiota
Yasna Azizpour,1Sedigheh Safari,2Fatemeh Ghafari,3,*
1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. 2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. 3. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Introduction: The relationship between the human gastric microbiota and reciprocal symbiotic with the host is the complex and homeostatic imbalance may lead to digestive diseases. Also targeted therapies in H. pylori infections may inadvertently harm the gastric microbiota, decreasing microbial diversity. While eradicating H. pylori might be beneficial in treating certain conditions, it could also negatively affect the balance and health of the entire microbial community. The severity of H. pylori infection largely depends on the complex bacterial pathogenic factor, gastric environmental factors, and host genetics. Studies have reported this infection is an agent associated with gastritis and gastric cancer at the early stage.
Methods: The present study is a review study that was conducted in 2023. Related articles were gathered by searching keywords, Gastric cancer, H. pylori, and gastric microbiota in Google Scholar, PubMed, Science Direct databases
Results: Studies show H. pylori infection has been confirmed as a major risk factor in gastric cancer. Stomach infection causes the premalignant environment of intestinal atrophy and metaplasia and causes changes in gastric microbiota and gastric auto-tumorigenesis. The most abundant types of bacteria in the stomach, proteobacteria and firmicutes, Bacteroides, actinobacteria, and fusobacteria also present in significant numbers. Similar studies showed an increase in the Frequency of Lactobacilli and Lacnospirases in the tissue samples of gastric cancer patients.
Conclusion: Advances in the techniques used in molecular and sequencing technologies have improved our understanding of the biology of H. pylori the host responses to this bacterium and the role of the gastric microbiota. Recent investigations have yielded substantial findings concerning the influence of H. pylori infection on the gastric microbial composition, gut dysbiosis, and cancer progression symptoms.