CEREBROSPINAL FLUID INJECTION REDUCED RECOVERY TIMES AFTER MILD TRAUMATIC BRAIN INJURY
CEREBROSPINAL FLUID INJECTION REDUCED RECOVERY TIMES AFTER MILD TRAUMATIC BRAIN INJURY
Samira Malekzadeh,1,*
1. Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Introduction: Following the aging process, the secretion of cerebrospinal fluid (CSF) decreases, leading to the accumulation of amyloid plaques in Alzheimer's disease and increased phosphorylation of tau protein in acute encephalopathy.
Methods: Traumatic brain injury (TBI) is a brain dysfunction that results from external trauma or impressive acts that due to brain weight loss. Average recovery from mild TBI occurs within one week to three months. Additionally, the mean duration of mild TBI was associated with orthopedic injury, cognitive impairment, depression or anxiety, drug use, age of injury, and female gender. CSF plays an important role in protecting the brain and spinal cord from mechanical damage and in effective processes/injuries that lead to a reduction in brain weight.
Results: CSF contains substances necessary for the brain, such as nutrients and hormones. On the other hand, CSF plays an important role in the clearance of CNS proteins important for cognitive function. After injury, the level of cognitive function decreased. Furthermore, intracranial pressure (ICP) was increased after injuries such as stroke, hydrocephalus, oedema, and traumatic brain injury (TBI).
Conclusion: CSF plays an important role in ICP homeostasis, and as a result, disturbance of CSF secretion or drainage may lead to high level of ICP. TBI is associated with other problems such as oedema, impaired tissue perfusion and increased ICP. AQP4 expression is altered in many diseases, including central nervous system (CNS) injury, ischaemia, hypoxia, and TBI. Elevated size of ventricular and pressure of intraventricular in aged populations with hypoxia conditions is proof. CSF administration shortened the mean recovery time of mild TBI or cognitive impairment. Additionally, average recovery from mild TBI was lower for female compare to male.