• The role of platelet derived exosomes in regenerative medicine
  • Seyyede Fatemeh Shams,1 Mohammadreza Javan,2 Faeze Shahriyari,3,*
    1. Department of hematology and blood banking. Faculty of medicine. Mashhad University of medical sciences. Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences
    2. Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Canada
    3. 4. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran.


  • Introduction: Exosomes are a group of extracellular vesicles that are released from the membrane of every live cell. They are 30-100 nanometers in diameter[1]. Exosomes are found naturally in body fluids such as blood, saliva, milk, urine, etc.; for this reason, they can be effective in both paracrine and endocrine ways[2]. Based on this, it can be said that exosomes are involved in biological activities such as homeostasis, coagulation, inflammation, angiogenesis, removal of unnecessary proteins and mRNA, and pathological activities such as cancers and infections[3-5]. A large part of blood exosomes are derived from platelets. They are released from platelets as a result of high shear stress, platelet activation under the influence of agonists, or apoptosis[6]. They have a cup-like structure. Their surface is rich in exosome diagnostic markers such as CD9 , CD63. It also has platelet markers such as GPs GP IIb/IIIa, GP Ib/V/IX )[7-10]. Platelet exosomes are rich in growth factors . The use of platelet exosomes does not have side effects such as immunogenicity and tumorigenesis[7-14]. Various studies have been conducted on the effectiveness and usefulness of exosomes derived from platelets in regenerative medicine.
  • Methods: Based on the articles in PubMed and Google Scholar databases, this review has briefly examined the role of platelet exosomes in regenerative medicine.
  • Results: Platelet exosomes have the ability to store and transport important biomaterial such as the compounds found in platelet granules, as well as drugs. For this reason, they have received much attention in regenerative medicine. Platelet exosomes play a very strong and important role in various branches of regenerative medicine, such as wound healing and angiogenesis, nerve cell regeneration, musculoskeletal damage repair, and hair loss treatment
  • Conclusion: The results of this study show that these micro particles have low immunogenicity, low thrombogenicity, and they are very useful and efficient in regenerative medicine
  • Keywords: Exosomes; Growth factors; Platelets; Regenerative medicine