• Magnetic nanovesicles for the diagnosis and treatment of neurological diseases
  • Sara Salatin,1,*
    1. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


  • Introduction: Neurological diseases are increasingly being recognized as a global health challenge worldwide. There are significant issues for effective diagnosis and treatment of neurological diseases due to the presence of central nervous system (CNS) barriers. Magnetic nanovesicles are now well suggested as a potential theranostic option for improving the management of neurological disorders.
  • Methods: This work provides a summary of major CNS disorders and the physical barriers limiting the access of imaging/therapeutic agents to the CNS environment. The unique features of magnetic nanovesicles are discussed. Furthermore, a deeper understanding of magnetic nanovesicles as a promising combined strategy for diagnostic and/or therapeutic purposes in neurological disorders is provided.
  • Results: The diagnostic or therapeutic efficacy of nanovesicles can be significantly expanded by the addition of magnetic targeting, provided by the incorporation of magnetic nanoparticles. Magnetic nanovesicles are able to enrich at the target position, enhance cellular uptake, improve therapeutic efficacy, and thus minimize adverse effects of drugs under a magnetic field.
  • Conclusion: The multifunctionality of magnetic nanovesicles offers the ability to overcome the CNS barriers and can be used to monitor the effectiveness of treatment. Various in vivo experiments have demonstrated that magnetic nanovesicles possess remarkable potential for the management of neurological disorders. Although some issues need to be addressed, magnetic nanovesicles-based therapies will afford an effective theranostic strategy for neurological disorders in the future.
  • Keywords: Central nervous system (CNS), blood-brain-barrier (BBB), nanovesicle, magnetic nanoparticles