Investigating the potential of menstrual blood stem cells in regenerative medicine
Investigating the potential of menstrual blood stem cells in regenerative medicine
Sarah Mohammaditirabadi,1Saba Safdarpour,2,*Sajad Sepehrirad,3
1. Department of biology, College of Science, University of Tehran, Tehran, Iran 2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran 3. Faculty of Modern Sciences, Islamic Azad University of Medical Sciences, Tehran, Iran
Introduction: Menstrual blood-derived stem cells (MenSCs) are a novel source of mesenchymal stem cells (MSCs); that have several advantages including abundance, periodic acquisition, non-invasive isolation from donor women in the age of 20 to 45 years, high proliferation rate (doubling every 20 h supplied with sufficient culture conditions), possess multi lineage differentiation potency, migrate into injury sites, secretion of soluble factors, regulation of immune responses and stably genetic characteristic, the possibility of injecting large amounts of cells intravenously into the target tissue.
The purpose of this study is to investigate the potential of menstrual blood stem cells in regenerative medicine.
Methods: In the present review article, we studied original and review studies published in PubMed, Science Direct, Scopus, and Google Scholar databases using the keywords menstrual blood stem cells; assisted reproductive technologies; and regenerative medicine.
Results: Recent studies have shown that these stem cells, which are considered a type of biological waste, have a very high potential in the treatment of various levels of diseases and injuries due to fewer problems compared to transplantation and other expensive and invasive treatment methods. The risk of rejection and tumor formation in them is less. Also, there is no limit in terms of collecting these cells, and it is possible to receive these cells continuously and monthly, without the risk of infection for the donor. Despite the potential of MenSCs in regenerative medicine, there are several challenges that researchers will need to overcome to realize their full therapeutic potential and answer many questions.
Conclusion: In conclusion, the potential of menstrual blood stem cells in regenerative medicine offers great promise. With continued research menstrual blood stem cells may become a valuable source of stem cells for regenerative therapies. Overcoming challenges and advancing research in this area could lead to new and effective treatment options for patients with various medical conditions.