INVESTIGATION THE EFFECT OF COMMON MUTATIONS OF TRPM8,SUGCT,UFL1-AS1 GENES IN MIGRAINE PATIENTS IN TEHRAN
INVESTIGATION THE EFFECT OF COMMON MUTATIONS OF TRPM8,SUGCT,UFL1-AS1 GENES IN MIGRAINE PATIENTS IN TEHRAN
Maryam Rahmani,1,*Faranak jamshidian*,2
1. Department Of Biology,East Tehran Branch,Islamic Azad Unversity,Tehran,Iran 2. Department Of Biology,East Tehran Branch,Islamic Azad Unversity,Tehran,Iran
Introduction: Migraine continues second among the world’s causes of disabilitymost people who have -there are 4 types of migraine headaches: frontal, temporal, occipital and rhinogenic.Preventive therapy may also improve quality of life and prevent the progression to chronic migraines. Some indications for preventive therapy include four or more headaches a month, eight or more headache days month, debilitating headaches, and medication-overuse headaches. Migraine is a complex brain disorder that is explained by the interaction of genetic and environment factors.Genetic studies have also shown the importance of common genetic factors between migraine and diseases such as depression and high blood pressure.
Methods: Using the PCR technique and gel electrophoresis,we check the SNP sequences of TRPM8,SUGCT and UFL1-AS1 genes.
Results: Results from twin studies show that genes play an important role for susceptibility to migraine. The propensity for migraine to run in some families but not in others arises predominantly from alleles shared by family members and not the shared family environment, and that environmental influences on migraine are unique to the affected family memberSNPs
Conclusion: This project helps us to inform the patient about the occurrence of mutations in the desired genes and
the risk of developing migraines.domain 16(PRDM16) gene, the rs10166942 near the transient receptor potential cation channel subfamily M member 8 (TRPM8) gene, However, data from subsequent studies examining the role of these variants and their relationship with migraine remain. as well as CYP2C9*2 and the rs4379368 mutations, have all been identified as genetic predictive risk factors of VTE in women. is within the four and a half LIM domains protein 5 (FHL5) gene. allele AA or AG genotype of rs13208321 were associated with a reduced risk of migraine.