Introduction: Alzheimer's disease (AD) is a complex, highly heritable disease with no current effective prevention or treatment. Genetic factors play an important role in the occurrence and development of this disease. Despite decades of research, there are no effective treatments and a large part of the genetic heritability remains unknown. Therefore, in this research, the relationship between these mutations and the incidence of disease in Tehran is investigated. The aim of this study is to investigate the effect of common mutations of APOE, ABCA7 and TREM2 genes in patients with Alzheimer's disease in Tehran.
Methods: In this study, samples from 100 Alzheimer's patients and 100 non-relative healthy controls who matched the patient group in terms of geography, age, gender, were performed using the PCR method
Results: The studied population was investigated according to the Hardy-Weinberg law, which, according to the significance of the polymorphisms rs3764650 (p-value: 0.106) and rs429358 (p-value: 0.6863), the non-significance of these polymorphisms with Alzheimer's and polymorphism rs75932628 ( p-value: 0.0167) has shown its significant relationship with Alzheimer's disease
Conclusion: The present study emphasizes the importance of examining genetic factors in Alzheimer's disease and can help identify patients at risk and develop prevention strategies. It is suggested that more research be done on the relationship between genetic mutations and environmental factors in this disease in order to gain a better understanding of its mechanisms
Keywords: Alzheimer's - mutation - single nucleotide polymorphism - gene