Diba Shafiee,1Saman hakimian,2,*
1. Islamic Azad Microbiology bachelor degree North Tehran Branch University 2. M.sc student of Pathogenic Microbes Islamic Azad University Central Tehran Branch
Introduction: Introduction
Cancer is a progressive and fatal disease that is very common in the world today and it can be said that it is among the ten leading causes of death in the world, for this reason biologists are making great efforts to provide more effective methods instead of using old and destructive methods such as Radiation therapy, chemotherapy and drug therapy and preventing the increase in drug resistance that we face after a while from new methods with minimal side effects such as cancer immunotherapy, using the unique characteristics of bacteria and viruses and bacteria-based products. Use in the treatment of cancer.
Methods: Material methods:
The use of the properties of bacteria in cancer treatment is still not common and today it has a long way to use as a conventional method, but new research has proven that a species of bacteria with special properties can be an effective method for targeted cancer treatment. .The use of bacteria in cancer treatment has side effects that have been minimized with the help of genetic manipulation. Weakened, killed and genetically modified bacterial species that are nonpathogenic are able to selectively multiply in tumors and inhibit their growth. Innate and adaptive responses that include the release of pro-inflammatory cytokines that give the immune system the ability to destroy multiple tumors. Many of these therapies, such as programmed death protein, checkpoint inhibitors, etc. They are used with extremely effective results.
Results: Results:
Mycobacterium bovis, Listeria monocytogenes, Salmonella typhimurium, Escherichia coli, Streptococcus and Clostridium. According to the characteristics of microorganisms, their genes can be changed in such a way as to change their capacity to produce and release chemicals. A special poison that has anti-cancer properties. Bacteria are also used as carriers of anti-cancer drugs.
Conclusion: Conclusion:
Bacteria such as E. coli, Escherichia coli, Salmonella, Streptococcus and Clostridium and many other bacteria that have special features such as biofilm formation, enzyme production, bacteriocin production and many other features that make the species of bacteria special can be found in these features. In the direction of cancer treatment with less complications, considering that in future studies, a lot of work should be done on the disadvantages of using bacteria in treatment in order to be on the path of widespread use all over the world.