Investigating the autoimmune disease of rheumatoid arthritis and the genetic factors involved in the development of this disease
Investigating the autoimmune disease of rheumatoid arthritis and the genetic factors involved in the development of this disease
ramin shokripour,1ramesh ranjbar,2,*
1. department of genetics, marvdasht branch, islamic azad university, marvdasht, iran. 2. PhD student, Department of Genetics, Faculty of Basic Sciences, Shahrekord Islamic Azad University, Shahrekord, Iran
Introduction: Rheumatoid arthritis (RA) is an incurable systemic autoimmune
disease. The progression of the disease leads to joint deformity and related loss of function,
which significantly affects the quality of life of sufferers.The objectives of the present review are to provide an overview of RA, including a general
introduction to the disease, epidemiology, risk factors and pathogenesis, to highlight the progress
of basic disease research and the various signaling pathways and molecular mechanisms,
including genetics.
Methods: this research is a review study and databases such as NCBI,PUBMED,...have been used in this research.
Results: In the past few decades, RA has attracted more researchers' attention,
abnormal signaling pathways in RA is a very important research field in the diagnosis and
treatment of RA, which provides important evidence for understanding this complex disease and
developing interventions related to RA provides.
Conclusion: RA pathogenesis is related to many signaling pathways. The cause of
RA has been investigated several times, and studies show that environmental and genetic factors
are important in the induction of RA. Also, some studies have shown that the sensitivity and
severity of RA may be related to the HLA-DRB1 allele, which has the strongest genetic
association with RA.