• Examining the signaling pathway of autoimmune diseases
  • ramin shokripour,1 ramesh ranjbar,2,*
    1. department of genetics, marvdasht branch, islamic azad university, marvdasht, iran.
    2. PhD student, Department of Genetics, Faculty of Basic Sciences, Shahrekord Islamic Azad University, Shahrekord, Iran


  • Introduction: Autoimmune diseases are a diverse group of conditions characterized by aberrant reactivity of B cells and T cells to natural components of the host. This disease occurs especially in women and it affects people of age. In general, autoimmune disease is caused by an interaction between a genetic predisposition and environmental factors. Genetic predisposition to autoimmunity is complex and can involve multiple factors that shape immune cell function. Less commonly, autoimmunity can result from single-gene mutations that affect key regulatory pathways.
  • Methods: This research is a review study and Iranian and foreign databases like PUBMED, NCBI, etc. have been used in this research to collect information.
  • Results: According to the obtained research, the cause of this disease is between genotype and environment. Many genes involved in this disease can be located in common biological networks
  • Conclusion: According to the studies: Rheumatoid arthritis, which has the strongest relationship with PTPN22 and HLAo IL23R genes. Graves' disease and SLC25A16 gene, lichen planus disease and CDKN2A tumor suppressor gene changes, Hashimoto's thyroiditis and myasthenia gravis, CTLA4 gene, RAG gene involved in autoimmune vasculitis disease and... is the autoantigen of existence / Shogren's syndrome SSNA1/NA14, disease. Protein tyrosine phosphatase PTNP22 and... which is discussed in this study.
  • Keywords: autoimmune disorders, signaling pathway, genetics and outoimmunity