Healing Potential of Targeting MicroRNAs in Acute Myeloid Leukemia Treatment
Healing Potential of Targeting MicroRNAs in Acute Myeloid Leukemia Treatment
Nikta Mohajerani,1,*Saman Hakimian,2
1. M.sc student of Hematology Shahid beheshti university of medical science 2. M.sc student of Pathogenic Microbes Islamic Azad University Central Tehran Branch
Introduction: Acute myeloid leukemia (AML) is a neoplastic disorder characterized by the clonal proliferation of immature myeloid hematopoietic cells within the bone marrow, exhibiting rapid advancement and a generally unfavorable prognosis. In recent decades, significant advancements have been made in understanding the genetic anomalies that influence the progression of (AML). Most types of leukemia lack the development of dependable treatment options. Additionally, even therapies considered somewhat effective may lead to disease recurrences.
Methods: In the context of AML, microRNAs (miRNAs) are considered a valuable enhancement to the restricted range of therapeutic options available, and extensive research has been conducted on the dysregulation of miRNAs. Micro RNAs (miRNAs) represent a category of small non-coding RNAs that play a vital role in various cellular functions, including differentiation, proliferation, migration, and apoptosis. From a clinical perspective, numerous miRs have been identified as correlating with the prognosis of patients with AML. Oncogenic microRNAs are associated with unfavorable outcomes.
Results: This review will focus on Gaining insights into the role of microRNAs in the pathology of Acute Myeloid Leukemia (AML) and Learning about emerging strategies that involve targeting microRNAs as a novel therapeutic avenue to enhance AML treatment outcomes.
Conclusion: MicroRNAs hold significant promise as a transformative approach to diagnosing and managing acute myeloid leukemia.