• MIR7-3HG Long non-coding RNAs and testicular germ cell tumors (TGCT): an update of potential biomarkers
  • Amir Arsalan Aghabozorgizadeh,1,*
    1. department of cell and molecular biology and microbiology, faculty of science and technology, university of isfahan, isfahan, iran


  • Introduction: Malignant testicular tumors are rare, but testicular germ cell Tumors (TGCT) is the most common cancer among men between 15 and 40 years of age and is the leading cause of cancer-related mortality and morbidity in this age group. Although it has been shown that the expression of many genes play a role in the pathogenesis of this disease, there is little information about the changes in the expression of MIR7-3HG long non-coding RNA in this cancer. The aim of this study was to investigate the expression changes of MIR7-3HG gene in TGCT and introduce it as a diagnostic and prognostic biomarker.
  • Methods: In order to investigate the expression changes of MIR7-3HG in TGCT, TCGA data provided by oncodb database was used. Also, the Roc-curve chart was used to evaluate the diagnostic biomarker potential.
  • Results: Our results showed that the expression level of MIR7-3HG non-coding RNA in cancer samples of TGCT patients is significantly increased compared to normal samples (log FC=-4.8, p-value 1.1e-29, FDR < 0.001). Also, the ROC-curve chart indicated that the expression changes of this gene can be used as a diagnostic biomarker to diagnose people with this type of cancer (AUC = 0.9987, p-value < 0.0001).
  • Conclusion: The results of our study showed that the expression level of MIR7-3HG is decreased in TGCT patients. We also showed that the expression level of MIR7-3HG can be considered as a diagnostic and even prognostic biomarker.
  • Keywords: MIR7-3HG, long non-coding RNAs, TGCT, biomarker