• Flavonoid compounds of myristica fragrans extract and male infertility treatment
  • Zeynab Toluei,1,* Zahra Mirzakarimi,2
    1. Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran
    2. Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran


  • Introduction: Myristica fragrans )Nutmeg) is a fragrant spice obtained from the evergreen nutmeg tree. The nutmeg tree is native to the Pacific Islands and can be found from Asia to Australia. It is mostly used as a spice due to its distinctive spicy and sweet aroma. In traditional medicine, nutmeg is used to increase fertility, regulate blood pressure, improve digestive system function, remove kidney infection, treat rheumatism, etc. Pharmacological studies have shown that myristica seeds have antioxidant properties and help in the treatment of infertility and sperm disorders. According to studies, antioxidants reduce the effect of factors that cause these disorders, i.e., oxidative stress. Its secondary metabolites, including flavonoid compounds, play an important role in the treatment of male infertility.
  • Methods: In this study, the number of flavonoid compounds was investigated to show the antioxidant properties. At first, extraction was done by hot (Soxhlet) method, and then rotary extraction was done to remove 70% alcohol. The obtained extract was reacted with aluminum chloride for 30 minutes. The absorbance of the formed complex was measured at 415 nm. The flavonoid values in the sample were determined according to the quercetin standard curve.
  • Results: The amount of this compound in extract is 27.043 quercetin (μg).
  • Conclusion: Considering that the flavonoid properties found in natural products represent the antioxidant capacity. According to the results, it can be said that nutmeg can neutralize the effects of oxidative stress and treat the damage caused by its effects. Therefore, it can be an effective drug for the treatment of sperm disorders and the treatment of male infertility.
  • Keywords: myristica fragrans, Flavonoid compounds , Antioxidants, Treatment of male infirtility