Immune system resistance against the fungus Blastomyces dermatitidis
Immune system resistance against the fungus Blastomyces dermatitidis
neda korkorian,1tala hayati,2,*Hoorie Hashemi Fesharaki,3Amir Sadeghi,4
1. Department of Microbiology.Faculty of Biological Sciences. Falavarjan Branch Islamic Azad University 2. Department of Microbiology.Faculty of Biological Sciences. Falavarjan Branch Islamic Azad University 3. Department of Microbiology.Faculty of Biological Sciences. Falavarjan Branch Islamic Azad University 4. .
Introduction: Blastomycosis is a pulmonary disease caused by the dimorphic fungus, Blastomyces dermatitidis. Immunosuppression is a major risk factor that affects disease susceptibility, but host immunity is poorly understood. Genetic immunodeficiencies can also impact the disease.
Methods: This review study collected data from scientific databases such as SID, Google Scholar, PubMed, Scopus, and Science of Web to find published texts from 2015 to 2024. Keywords included Blastomyces dermatitidis, immune response, interaction, and host. Selected articles were in Persian or English and had full-text access. To evaluate the extracted articles, their relevance to the research topic was first determined using the titles and abstracts. The remaining articles were then examined in terms of content, focusing on the importance and host immune system against Blastomyces dermatitidis fungi. Finally, 15 relevant articles were selected.
Results: The results showed that GM-CSF, TNF-α, CD4+ deficiency, and IL-12 and IFN-γ pathways had the most evidence as susceptibility factors for Blastomyces dermatitidis.
Conclusion: The findings of this research can inform clinical practice to improve outcomes by better understanding host immunity and genetic susceptibility to blastomycosis.