The effect of hydroalcoholic extract of of Berberis integerrima membrane on blood coagulation in mice
The effect of hydroalcoholic extract of of Berberis integerrima membrane on blood coagulation in mice
Fatemeh Sadeghi Far,1,*Masoud Fereidoni ,2Nadia Mehrdad,3
1. Department of Biology, Faculty of science, Hakim Sabzevari University of Sabzevar, Iran 2. Department of Biology, Faculty of science, Ferdowsi University of Mashhad, Iran 3. Department of Biology, Faculty of science, Hakim Sabzevari University of Sabzevar, Iran
Introduction: Berberis integerrima is a plant known for its traditional medicinal uses and numerous health benefits, such as treatment of high blood pressure, diabetes, cholesterol, various infections and inflammation, liver dysfunction and digestive disorders.
Various compounds including alkaloids, bioactive and phenolic compounds have been reported for this plant.
Studying the pharmacological properties of its active ingredients is important to further understand its therapeutic potential.
Methods: In this study, the effect of different concentrations of Berberis integerrima hydroalcoholic extract on blood coagulation parameters has been investigated, specifically prothrombin time (PT), Partial Thromboplastin Time (aPPT), Clotting Time (CT) and Bleeding time (BT) in male mice over a period of 21 days.
Results: The results of the study revealed that the Berberis integerrima extract had a significant impact on the coagulation indicators at high doses (750 mg/kg). However, low doses (100 mg/kg) showed no significant effect. Certain alkaloids and flavonoids present in the extract may have anticoagulant properties, inhibiting the process of blood clotting.
Conclusion: Additional research is necessary to explore the potential of using Berberis integerrima extract in treating coagulation disorders resulting from deficiencies in coagulation proteins.In addition, this study can help to optimize the clinical use of Berberis integerrima and serve as a basis for future research in the field of treating cardiovascular diseases such as atherosclerosis, Myocardial infarction, and cerebral strokes.