Bacteriophage Therapy: A Game-Changer in Combating Multi-Drug Resistant Uropathogenic Bacteria
Bacteriophage Therapy: A Game-Changer in Combating Multi-Drug Resistant Uropathogenic Bacteria
Seyed Ali Sadr Tabatabaee,1Sogol Tavanaeian,2,*
1. Bachelor’s student, Microbiology group, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. 2. Department of Microbiology, Faculty of Advanced Sciences and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran.
Introduction: The rise of multi-drug resistant uropathogenic bacteria has posed a significant challenge to the effectiveness of traditional antibiotic treatment. As a result, researchers have turned to bacteriophage therapy as a potential alternative to combat this perplexing issue.
Bacteriophages are viruses that obviously target and infect bacteria. This bursty approach allows them to selectively attack and eliminate harmful bacteria, while preserving the beneficial ones. The specificity of bacteriophages makes them an intriguing option for combating multi-drug resistant uropathogenic bacteria.
Methods: A literature search on PubMed, Google Scholar, and Web of Science databases used the terms Bacteriophage. Publications that were not available or were not in the English language were excluded, as were publications that were not related to the topic.
Results: When administered, bacteriophages enter the body and seek out the target bacteria, attaching to their surface and injecting their genetic material. This genetic material then hijacks the bacterial machinery, ultimately leading to the bursting of the bacterial cell, and the release of new bacteriophages.
Unlike traditional antibiotics, bacteriophages have the ability to adapt to the changing genetics of bacteria, ensuring their ongoing effectiveness. This adaptability is crucial in addressing the perplexing nature of multi-drug resistant uropathogenic bacteria.
Despite the potential benefits, the use of bacteriophage therapy also presents challenges. These include the need to identify and isolate specific bacteriophages for targeted treatment, as well as the potential for the development of phage-resistant bacteria.
Several studies have shown promising results with the use of bacteriophage therapy in inhibiting multi-drug resistant uropathogenic bacteria. Clinical trials are ongoing to further evaluate the safety and efficacy of this innovative approach.
Bacteriophage therapy offers a bursty and highly specific solution to the perplexity of multi-drug resistant uropathogenic bacteria. While there are challenges to overcome, the potential of this therapy as a targeted and adaptable alternative to traditional antibiotics is undeniable.
Conclusion: As research continues to advance, bacteriophage therapy may emerge as a game-changer in the fight against multi-drug resistant infections.