An overview of the role of microbiomes in the severity and severity of colorectal cancer
An overview of the role of microbiomes in the severity and severity of colorectal cancer
ramesh ranjbar,1,*
1. 1- PhD student, Department of Genetics, Faculty of Basic Sciences, Shahrekord Islamic Azad University, Shahrekord, Iran.
Introduction: Microbiome means microbes coexisting with the host, regardless of the species, in a part of the body of an organism called microbiome. Nowadays, changes in gut microbiota are considered as a potential therapeutic approach for the prevention or treatment of colorectal cancer (CRC).
Methods: This research is a review study .databases such as NCBI, PUBMED, etc have been used in this research to collect information
Results: Studies have shown that dietary habits and lifestyle play a role in modulating the gut microbiota.
Intestinal microbiota play a role in converting food components into oncometabolites. Some studies showed that Shigella, Citrobacter and Salmonella bacteria are more abundant in the early stages of cancer compared to healthy people. The aim of this study is to review the role of microbiomes in the development of colorectal cancer and the metabolites produced by microbiomes in the development of colorectal cancer.
Conclusion: In total, the studies show that the separation of genetic factors and genes involved in the development of this disease and especially familial CRC; The type of intestinal microbiota and the food pattern and lifestyle of a person play a role in causing this condition. It should be noted that dietary pattern plays a role in the proliferation of microbiota that produce carcinogenic products.