• Effect of antioxidant activity of nanochitosan carrying the extract of Lepidium draba L plant on the liver tissue of rat infected with Staphylococcus aureus
  • Anahita Sinaei,1,* Zahra Kashtmand,2 Morteza Mohajeri Amiri,3
    1. Department of Biology, Scientific and Research Unit, Azad Islamic University, Tehran, Iran
    2. Department of Biology, Central Tehran Branch, Azad Islamic University, Tehran, Iran
    3. Department of Biology, Scientific and Research Unit, Azad Islamic University, Tehran, Iran


  • Introduction: Today, nanocarriers are of particular importance, because they can improve the bioavailability and efficacy of the compound by passive or active targeting to damaged tissues. On the other hand, medicinal plants are good candidates for the treatment of diseases, and one of the most valuable medicinal plants of the shabbo family is the Lepidium draba L plant. Chitosan is a non-toxic, renewable nanocarrier that acts as a compatible and effective biological material. The purpose of this research. Investigating the effect of antioxidant activities of nanochitosan carrying the extract of Lepidium draba L plant on liver tissue infected with Staphylococcus aureus bacteria in male Wistar rats
  • Methods: In this experimental study, 28 male Wistar rats were divided into four groups, including the control group, infected with Staphylococcus aureus (108 CFU/ml), recipient of nanochitosan (1 ml) and the infected model + recipient of nanochitosan carrying the extract of Lepidium draba L plant (200 mg/ kg) were divided. Induction of infection was done by intraperitoneal injection and receiving the extract of plant-carrying nanochitosan for 35 days by gavage method. After the treatment and dissection of the animals, the liver tissue was extracted to check the level of antioxidant activity of TAC and MDA in different groups. Data analysis in different groups was done with SPSS software and one-way variance statistical test and p<0.05 was considered significant.
  • Results: The results showed a significant change in the level of antioxidant activity of TAC and MDA in the infected groups compared to the control group. While the increase of TAC activity and the decrease of MDA in the treatment groups compared to the infected group were shown significantly.
  • Conclusion: Based on the obtained results, nano-chitosan carrying the extract of Lepidium draba L plant showed a modulating effect on the antioxidant activity of the liver tissue of rat infected with bacteria. Therefore, it can probably be used as a promising therapeutic tool, although it is suggested that gene pathways, molecular pathways and tissue changes should be taken into consideration in the next investigations.
  • Keywords: Nanochitosan, Lepidium draba L plant , TAC, MDA, liver, Staphylococcus aureus, Rat