• The Application of Stem Cells in Tissue Engineering for Craniofacial Bone Regeneration
  • mehrnaz saadat fathi,1 Saba Safdarpour,2,*
    1. Faculty of Modern Sciences, Islamic Azad University of Medical Sciences, Tehran, Iran
    2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran


  • Introduction: Stem cells exist in many tissues such as bone marrow, fat, and skin, but the isolation of cells that have the ability to transform into other tissues is very expensive and is done with invasive methods that may damage the cell. Another tissue from which stem cells with high potential can be extracted are dental follicles. Dental follicle stem cells are a group of dental mesenchymal cells that play a role in the growth and maintenance of teeth. These cells can be a good choice due to their ability to transform into different tissues. By studying a series of genes in these cells, it was shown that these cells have the capacity of self-renewal and have great potential to transform into all kinds of tissues. Researches mention that DFPCS possessed more similar protein profile cranial neural crest cells (CNCCs) compared with dental plup stem cell (DPSCs). The purpose of this study is to The Application of Stem Cells in Tissue Engineering for Craniofacial Bone Regeneration.
  • Methods: In the present review article, we studied both original and review studies published in PubMed, Science Direct, Scopus and Google Scholar database using the key words Tissue Engineering; Craniofacial Bone Regeneration; Stem Cells
  • Results: As we mentioned earlier, DFPC’s are an important type of dental stem cells that originate from dental follicles, and they can be widely used due to the transformation into different types of cells like Osteoblasts, cement oblasts, adipocytes and (PDL) cells. Also, DFPC’s can be harvested from discarded tooth conveniently and noninvasively, which has led to lower costs and easier access to these cells, these two reasons make these cells a very good source for obtaining cells with It has become highly versatile.
  • Conclusion: According to the previous material, we hope to use DFPC’s because of the low extraction cost and easier access compared to other stem cell sources. It’s hoped that in the near future we’ll be able to use this method in treatment of facial defects.
  • Keywords: stem cell, Tissue Engineering, Craniofacial Bone Regeneration