Investigating the antimicrobial effect of drugs in nanofiber bed containing chitin on secondary infection of diabetic wounds
Investigating the antimicrobial effect of drugs in nanofiber bed containing chitin on secondary infection of diabetic wounds
Zahra Bayat Sarmadi,1,*Fatemeh Bayat Sarmadi,2
1. Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran 2. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
Introduction: Diabetic wounds are susceptible to secondary infections and significantly hinder healing, as a result, they can cause severe complications. Chitin is a biopolymer that may show promising healing properties when used alongside an antimicrobial drug. This review examines the efficacy of chitin-enriched nanofibers in combination with antimicrobial drugs as a novel therapeutic strategy to prevent secondary infections in diabetic wounds.
Methods: There were studies related to experimental sources that used chitin-based nanofibers in diabetic wound models. Keywords evaluated in these studies included "antimicrobial activity", "wound healing rate" and "biocompatibility". In this research, the mechanisms through which chitin nanofibers increase antimicrobial effects were analyzed.
Results: The investigations show that chitin nanofibers probably show a significant effect on antimicrobial activity against a range of pathogens that are usually associated with diabetic wound infections, including Staphylococcus aureus and Pseudomonas aeruginosa. In addition, it is observed that these nanofibers alone can heal open diabetic wounds, and in general can increase the rate of tissue healing and prevent the occurrence of secondary infections in these damaged tissues.
Conclusion: Chitin nanofiber is a promising therapeutic combination to manage the reduction of secondary infections in diabetic wounds. In addition to the antimicrobial properties of the combination of medicine and chitin, by emphasizing the healing of damaged tissue, it can prevent infection and other injuries. It seems that future studies should focus on optimizing the formulation of medicinal nanofibers and conducting clinical trials to evaluate their effectiveness in real environments.