• The role of cell therapy for dementia: A systematic review
  • Asal Heydarzadeh,1 Farzad Nezafati,2,*
    1. 7th grade (Middle school), Professor Shamsipour institue, Kermanshah, Iran.
    2. Department of Biology, Kermanshah branch, Islamic Azad University, Kermanshah, Iran


  • Introduction: Cell-based therapies are being developed for various neurodegenerative diseases affecting the central nervous system (CNS). Simultaneously, the role of individual cell types in neuropathology can be visualized by genetic and single-cell studies . Dementia may be characterized by confusion, behavioral disturbances, and cognitive impairment, and is currently said to affect approximately 50 million people worldwide, and is projected to increase to 132 million by 2050.
  • Methods: We systematically reviewed Dementia reviewed studies with the aim of identifying cell therapy method in Dementia. For this purpose, English language reviewed articles between 2019 and 2024 were searched in PubMed, databases. The titles of the articles were scanned with keywords (Dementia) and (Cell therapy).
  • Results: After studying the abstract, conclusion, results and sections of the selected articles, into two sections:1) Investigating the effects of cell therapy on Alzheimer's disease which is known as the most common type of dementia. 2) Investigating the effect of cell therapy on Parkinson’s disease was divided. We also reviewed the disadvantages and limitations and challenges of stem cell therapy and investigated the types of stem cells for the treatment of neurodegenerative diseases to get better results. Also we searched about other ways to treatment Dementia’s diseases and compare these ways with cell therapies method. Of course We also see effects of exosome and cell products that can be used instead of stem cell.
  • Conclusion: In this research we tried to the best cell for cell therapy way and compare with other ways to treatment dementia that We can find the best treatment and also what limitation and challenges we have.
  • Keywords: Cell therapy, Dementia, Stem cell