The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Traumatically Injured Patients at Admission: A Mini-Review
The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Traumatically Injured Patients at Admission: A Mini-Review
Maryam Hosseini,1,*Shahram Paydar,2Mahsa Hajivalili,3
1. Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran 2. Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran 3. Iran University of Medical Sciences
Introduction: Subsequent to trauma and systemic inflammatory response syndrome, the typical reaction is an increase in the total white blood cell count. Neutrophils, which play a crucial role in the initial immune response against invading microbes through phagocytosis and inflammatory mediators, are abundant circulating leukocytes in humans.
Methods: However, lymphocytes, the main cellular compartments of the immune system, are negatively affected in the setting of trauma. The neutrophil to lymphocyte ratio (NLR), which can be easily measured in daily clinical practices, is an alternative marker of inflammation before any clinical findings can be observed.
Results: Most investigations have declared that high values of NLR potentially have a poor prognosis in traumatically ill patients on admission and contribute to coagulopathy, increased hospitalization, and mortality.
Conclusion: Given that various cut-off points have been considered for the NLR value, receiving a unique one and linking it with subsequent outcomes of the disease should be the focus of ongoing research.