The effect of inflammation and angiogenesis, along with the use of corkomin and nanoparticles on p53 gene expression and the activity of proteins involved in apoptosis on breast cancer
The effect of inflammation and angiogenesis, along with the use of corkomin and nanoparticles on p53 gene expression and the activity of proteins involved in apoptosis on breast cancer
Introduction: Breast cancer has become the fifth most common cause of cancer. Due to the increase in malignancy and drug resistance, researchers have been concerned with the biggest public health problem and the most common malignancy among women over the past15 years. Cancer is one of the inflammatory patients whose immobility is a factor, and it seems that sports activities can play an important role by establishing homeostasis and modulating inflammation In the past few decades, many studies have been conducted on the factors affecting its incidence in many patients, which has proven to be conventional chemotherapy methods in the treatment of all subtypes before Milad is inadequate.Emphasis on the urgent need for therapeutic approaches or new drugs, curcumin:2A plant-based chemical derived from turmeric, a significant potential in inhibiting this disease along with apoptosis ,autophagy ,angiogenesis inhibition، Cellular migration, metastasis and proliferation are associated in this context.Challenges, due to their dynamic and easily biodegradable nature, poor water solubility, rapid metabolism, and rapid systemic elimination,collectively limit its clinical applications.which has been reviewed below.
Methods: This essay the collected data related to the use of keywords such as breast cancer,inflammation,curcumin
angiogenesis,P53gen,apoptosis without any time restrictions.A retrospective of research has been conducted that looks at promising strategies and potential pathways associated with the causes and factors involved in breast cancer, along with the effects of therapeutic aid factors such as the use of drugs plant quercumin, angiogenesis, levels of suppressant genes, apoptosis, and levels of proteins and prognostic factors and strategies for psychological adaptation to cancer and its impact on the quality of life of breast cancer sufferers.
Results: In this study, the study of about 23 articles, including research and research on the effect of factors affecting the breast cancer process and the need for use, as well as the emphasis on the urgent need for therapeutic approaches، New drugs and promising strategies have explored potential pathways associated with the causes and factors involved in breast cancer.
Conclusion: In recent decades, many efforts have been made to improve treatment and diagnosis methods and to study psychological compatibility with cancer and quality of life for women with it. Due to the complications of existing and common treatment methods for this surgical disease, radiation therapy, chemotherapy and its high costs، The use of novel nitrogen technologies to find new methods with fewer complications and costs has recently been considered.In this section, we examine several examples of these. One of the genes that mutates in breast cancer is the p53 gene. The rate of expression of the p53 gene in breast cancer has been reported differently in different areas.The most important prognostic and predictive factors of response to treatment are age, agglomerate lymph node involvement (N), estrogen receptor status (ER), progesterone (PR)، Human Growth Factor Epidermal HER 2, size of tumor 2, tumor 2, etc. ^53, cell projection such as 53.2. Today, about half of all breast cancers have estrogen and progesterone receptors on tumor cells, which in the presence of the above humons cause tumor growth. Estrogen has been identified as a mitogen for breast cancer cells. Aerobic exercises, through various mechanisms, including reduction of androgenic sex hormones, result in reduction estrogen.Physiological factors can regulate growth, metabolism, metastatic potential, and tumor safety profiles . The most common result of studies on the effect of exercise on cancer is a decrease in tumor growth. This inhibitory effect has been observed In recent decades, many efforts have been made to improve treatment and diagnosis methods and to study psychological compatibility with cancer and quality of life for women with it. Due to the complications of existing and common treatment methods for this surgical disease, radiation therapy, chemotherapy and its high costs، The use of novel nitrogen technologies to find new methods with fewer complications and costs has recently been considered.In this section, we examine several examples of these. One of the genes that mutates in breast cancer is the p53 gene. The rate of expression of the p53 gene in breast cancer has been reported differently in different areas.The most important prognostic and predictive factors of response to treatment are age, agglomerate lymph node involvement (N), estrogen receptor status (ER), progesterone (PR)، Human Growth Factor Epidermal HER 2, size of tumor 2, tumor 2, etc. ^53, cell projection such as 53.2. Today, about half of all breast cancers have estrogen and progesterone receptors on tumor cells, which in the presence of the above humons cause tumor growth. Estrogen has been identified as a mitogen for breast cancer cells. Aerobic exercises, through various mechanisms, including reduction of androgenic sex hormones, result in reduction estrogen.Physiological factors can regulate growth, metabolism, metastatic potential, and tumor safety profiles . The most common result of studies on the effect of exercise on cancer is a decrease in tumor growth. This inhibitory effect has been observed in all cancer cells examined.Overall, a thorough understanding of angiogenesis may lead to the identification of new therapies for cancer patients. Many studies show that exercise can inhibit tumor growth.Although most studies have examined the effects of endurance training on tumor tissue, little research has been done on the effect of periodic exercise on tumor tissue.It is included in many threatening tumors, glioblastoma counts, and in tumor movement.Laboratory studies on several types of cancer have shown that the destruction of miR-21 stifles cell expansion and tumor development, reducing metastatic penetration.A recent study, the combination of curcumin medicine insoluble in the blue systems, found in the mycelial structures known as aerobic exercise that promotes complete burning of fats, so aerobic exercise inhibits the rise of estrogen. Cholesterol is a precursor to steroid hormones, especially estrogen, which play an important role in breast cancer cells. Aerobic exercise by lowering cholesterol reduces estrogen.Selenium is present in the human body in the form of selenocysteine amino acids and is a constructive part of selenoproteins and has an important function in relation to an tioxidant activity. Selenium, on the other hand, with anticancer properties, especially through selenoenzyme, can prevent normal cell deformations into cancer cells and the activation of cancer genes in deformed cells.Amid the emergence of new methods, nanotechnology has been considered for direct anticancer treatments as well as for drug delivery. In fact, anticancer materials formed at the nanoscale have shown remarkable properties along with low toxicity..Interestingly, curcumin triggers the arrest of the cell cycle in BC cells.The cell cycle is a regular set of events that lead to cell growth and division 1 G, S, and 2 G phases and replicated cells protect DNA damage.CUR (CURCUMIN) is the proposed analog to enhance the protective function of BC cells in cell cycle arrest (68).Each stage is involved in the progression of the cancer، However, stage 1 G (which cells replicate themselves) is often considered to be particularly important in promoting cancer progression due to its initial position and function.Detention of COR(SLNs)Solid Lipid Nanoparticles in Cell cycle in G1/S and decreased cyclin D1(CCND1),CDK4, which greatly induces apoptosis and ROS reaction.
The results of studies also show. The reduction in tumor volume was due to aerobic periodic exercise and the use of selenium nanoparticles.Cancer has caused a significant reduction in the amount of IL-6, IL-4, and TNF-α cytokines in spleen tissue, but aerobic exercise and use and TNF-α in spleen tissue. Aerobic exercise and the use of selenium nanoparticles can play a role in strengthening the immune system and reducing tumor volume by increasing TNF-α cytokine as a TH1 cytokine complex.In the end, it can be pointed out،In this article, according to the research findings of the positive effects of high-intensity exercise and moderate-intensity therapy in reducing inflammation and other mentioned as therapeutic strategies in patients with Breast cancer, which may have positive or negative effects on carcinogenic mechanisms and the micro-tumor environment.
Keywords: Breast cancer, inflammation, curcumin, angiogenesis, P53 gene, apoptosis