Introduction: Alzheimer’s disease is a progressive neurological disorder that is the leading cause of dementia. It results in neuron cell death, personality changes, and significant disruptions in daily life. Given the potential therapeutic benefits of probiotics, this study explores the effects of native Iranian probiotics like lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus rhamnoses, Lactobacillus roteri, bacillus coagulans, bifidobacterium longum on memory impairment in male Wistar rats induced with Alzheimer’s disease. Specifically, the research focuses on evaluating the impact of these probiotics on tau gene expression in the brain, following exposure to beta amyloid.
Methods: The experiment was conducted on 15 male Wistar rats, which were divided into three groups of five. The first group served as the control and did not receive any treatment or undergo surgery. The second group, referred to as the Alzheimer’s group, underwent surgery where beta amyloid was administered using a stereotaxic device to induce Alzheimer’s like conditions. The third group, known as the Alzheimer’s + probiotic group, also underwent surgery with beta amyloid administration and subsequently received a 21-day course of probiotics via gavage.
Results: Following the gavage procedure, a shuttle box behavioral test was conducted on all groups to confirm the induction of Alzheimer’s disease. for tau gene expression levels were assessed using the PCR method.
Conclusion: According to the analysis of the obtained result, probiotics have a positive role in the heal of Alzheimer’s disease and the expression level of the tau gene has decreased in the group that received probiotics.
Keywords: Alzheimer’s disease, probiotics, beta amyloid, Rat, Tau gene