Introduction: Colorectal cancer (CRC) also known as bowel cancer, colon cancer, or rectal cancer remains one of the most frequently occurring cancers worldwide. Current standard therapeutic drugs have been associated with serious side effects that can be life-threatening for some patients. Extensive efforts have been undertaken to find alternative therapies.
Probiotics are useful and non-pathogenic microorganisms in the gastrointestinal tract. Probiotic bacteria are among new therapeutic options under evaluation. Lactobacilli strains are among the most used probiotics in CRC. The purpose of this study is observe how lactobacillus acidophilus effects on colorectal cancer.
Methods: for this research many groups of scientists used lots of different methods of culturing and analyzing like cell analysis , morphology analysis , real time PCR , using animal models and clinical trials on 398 men and women with previous colorectal tumors and the data were analyzed by statistical analysis.
Results: The results showed that based on the survival rate and harness of L. acidophilus extract, it inhibits the survival and proliferation of cancer cells in a dose- and time-dependent manner. In addition, various morphological changes were observed in the treated cancer cells, which are indicators of apoptosis induction.
Conclusion: The results of the present studies suggested that based on survival rate and harness of L.acidophilus , it inhibits the survival and proliferation of cancer cells in a dose- and time-dependent manner .and various morphological changes were observed in the cancer cells.
Keywords: Colorectal cancer , Lactobacillus acidophilus , Probiotics