• A review of gut microbiota composition in children with autism spectrum disorder
  • Marziyeh Mirzalou,1,* Mahdiyeh Mirzalou,2
    1. Department of Biological sciences and technologies, School of Medical Sciences., University of Azad marand Branch., marand, Iran
    2. Department of Biological sciences and technologies, School of Medical Sciences., University of Azad marand Branch., marand, Iran


  • Introduction: Autism spectrum disorder (ASD) is a chronic neurodevelopmental disorder with early onset, which has a prevalence of 1.7-0.6% among children, and this disorder has been steadily increasing in recent years.
  • Methods: This systematic review, to identify studies aimed at the effect of gut microbiota in children with autism spectrum disorder, search in Google Scholar, Science Direct, PubMed databases based on keywords Gut microbiota, Autism spectrum disorder, Children Was performed. After reviewing the summary of the articles and checking the title, the irrelevant articles were removed the full text of the articles was searched and the articles related to the topic were included in the study.
  • Results: According to the studies, people with ASD suffer from neuropsychiatric diseases and intellectual disability, digestive problems (GI), and eating and sleeping disorders. the bacterial characteristics of the intestinal microbiota are unique and different for each person according to age, lifestyle, and eating habits.
  • Conclusion: Treating the symptoms of autism and associated diseases by adjusting the intestinal microbiota by prescribing probiotics may increase the chances of successful treatment and ensure the quality of people's health.
  • Keywords: Gut microbiota, Autism spectrum disorder, Children