• Evaluation of The Importance of Non-High-Risk Human papillomavirus in High-Grade Cervical intraepithelial neoplasia
  • Dr Somayeh Ghasemzadeh,1,*
    1. Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran


  • Introduction: Infection with high-risk (HR) variants of the Human Papillomavirus (HPV) is the primary causative agent in the pathogenesis of cervical cancer, a disease that remains one of the most frequently diagnosed malignancies in the female population. Preliminary data from studies yet to be published indicate that certain HR HPV strains may be as contributory as HPV 16 and 18 in the progression to high-grade Cervical Intraepithelial Neoplasia (CIN). The aim of this investigation was to ascertain the association between these non-HR HPV strains and the occurrence of high-grade CIN.
  • Methods: An exhaustive literature review was conducted utilizing esteemed databases such as Ovid, Elsevier, PubMed, and Google Scholar. This review spanned publications from the years 2016 to 2024, with no restrictions based on the language of the articles. Initially, a total of 18 papers were identified. Following a meticulous process of summarization and analysis, 12 pertinent articles were ultimately chosen for inclusion in the study.
  • Results: In the methodically reviewed scholarly articles, a statistically significant association has been identified between the prevalence of HPV45 and the occurrence of CIN2. Moreover, the data indicates a profound linkage between HPV31 and the incidence of CIN3.
  • Conclusion: In light of the potential significance of HPV types in association with high-grade neoplasia’s, it is advisable to conduct comprehensive HPV typing analyses. Additional research is imperative to substantiate the findings presented herein.
  • Keywords: Human Papillomavirus, Neoplasia, Infection