1. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran. 2. Immunogenetic Research center, Molecular and cell Biology Research Centre, Mazandaran University of Medical Sciences, Sa
Abstract
Introduction
Spontaneous abortion is considered as the most complex problem during pregnancy. thrombophilia is resumed as a cause of recurrent pregnancy loss (rpl). glycoprotein iiia (gpiiia) gene is involved in thrombosis and abortion. in this study, we analyzed the association gpiiia c.98c >t in women with unexplained rpl from the north of iran.
Methods
Sample population consisted of 100 women with unexplained rpl and 100 controls.the gpiiia c.98c>t polymorphism was genotyped using tetra-arms pcr method. the association between genotypes frequency and rpl were analyzed using χp2p and exact fisher tests. associated risk with genotypes combinations was also investigated by binary logistic regression.
Results
No significant difference was observed between genotypic and allelic frequencies of gpiiia c.98c>t polymorphism and rpl in case and control groups.
Conclusion
The gpiiia c.98 c>t polymorphism was not significantly correlated with rpl.
