Combination of microrna-96 and microrna-126 may serve as diagnostic biomarker for detection of early stage non-small lung cancer: review

Zahra Bahmanpour,1,* Fatemeh radnia,2 Yousef daneshmandpour,3 Reza mousavi,4 Mahsa tahmasebi,5 Babak emamalizadeh,6

1. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
3. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
4. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
6. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction

Lung cancer is known as one of the most common fatal types of cancer worldwide. according to statistics, in 2017, it has been responsible for 155,870 deaths. non-small-cell lung cancer (nsclc) is one of the main types of lung cancer and accounts for a high percentage among different types. therefore, in order to try to reduce the mortality rate, many measures have been taken for early stage detection. today, micrornas are considered as potential biomarkers for the early detection of diseases, especially cancer. recently, extensive studies have been done on the roles of mirnas in nsclc

Methods

Recent studies by applying different methods on different stages of lung cancer in various clinical samples have represented that altered expression of mir-96 as oncomir and mir-126 as tumor suppressors has been determined to be involved in the pathogenesis of nsclc.

Results

According to studies, mir-96 in clinical specimen such as tissue and plasma of nsclc patients was significantly higher than normal subjects. also, in the case of mir-126 in the same clinical sample, there was a significant decrease in expressional level.

Conclusion

The present review reported significant changes in the expression level of mir-96 and mir-126 in patients with nsclc compared to non-cancer subjects, which point to the combination mir-96 and mir-126 for improving early detection of nsclc.

Keywords

Microrna-96, microrna-126, nsclc, early detection