Relationship between the status of helicobacter pylori baba2 and oipa genes and gastric cancer risk in iran

Omolbanin Feili,1,* Saber zahri,2 Saeid latifi-navid,3 Seyedeh zahra bakhti,4

1. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran
2. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran
3. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran
4. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 56199-11367, Iran

Abstract

Introduction

Helicobacter pylori (h. pylori) plays an essential role in the development of digestive diseases, such as non-atrophic gastritis (nag) and gastric cancer (gc). it has been shown that baba and oipa are the two important outer membrane proteins of h. pylori and are involved in the pathogenesis of the bacterium. the aim of present study was to analyze the relationship between h. pylori baba2 and oipa status and development of gc.

Methods

A total of 223 strains were obtained by culturing gastric biopsy specimens; then dna extraction and genotyping were performed.

Results

Frequency of baba2 and oipa genes in strains obtained from patients with nag (34.7%, and 63.9%, respectively) was higher than those with gc strains (6.3%, and 44.3%, respectively). the presence of baba2 and oipa genes showed a significant negative relationship with the risk of gc in logistic regression analysis; with odds ratio of 0.127 (95% ci= 0.048-0.335) and 0.450 (95% ci= 0.257-0.756), respectively.

Conclusion

In this study, we showed that infection with h. pylori strains carrying baba2 and oipa genes cannot threaten the risk of gc in iranian patients.

Keywords

Helicobacter pylori, gastric cancer, baba2, oipa, iran.