1. Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical 2. Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical
Abstract
Introduction
Coronary artery disease (cad) is a multifactorial genetic disease caused by the interaction between genetic and environmental factors. angiography is the gold standard method for the diagnosis and determining the stage of cardiac disorder. in this study, we focus on determining whether x-ray cross-complementing group 1 (xrcc1) polymorphism might be associated with increased risk for cad.
Methods
In this study, two polymorphisms in 287 patients and 229 matched controls were confirmed by angiography and analyzed. genotype analysis was carried out by polymerase chain reaction amplification followed by restriction fragment length polymorphism.
Results
A significant difference for the xrcc1 gene polymorphism (p= 0.002) and increasing severity of angiographic evidences of coronary artery disease was observed.
Conclusion
The significant association of the xrcc1 gene with the coronary artery patients in an iranian population have been detected. the introduction of candidate genes with other related variants can help the development of early diagnosis and effective interventional strategies that are safe, effective, necessary and individualized for cardiac patients.
